Disentangling the genetic underpinnings of neuropsychiatric symptoms in Alzheimer's disease in the Alzheimer's Disease Sequencing Project: Study design and methodology.

Nicholas R RayAjneesh KumarAndrew ZamanPamela Del RosarioPedro R MenaMasood ManoochehriColin SteinAlyssa N De VitoRobert A SweetTimothy J HohmanMichael L CuccaroGary W BeechamEdward D HueyChristiane Reitz

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)

Neuropsychiatric symptoms (NPS) are highly prevalent in Alzheimer's disease (AD).There are no effective treatments targeting NPS in AD.The current effort aims to collate, harmonize, and analyze all NPS data from the Alzheimer's Disease Sequencing Project.Core analyses will identify underlying genetic factors and mechanistic pathways.The harmonized genomic and phenotypic data from this initiative will be available through National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site.

Keyphrases

cognitive decline
quality improvement
big data
genome wide
gene expression
copy number
physical activity
machine learning
data analysis