John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis.
Dimitra S MouliouPublished in: Diseases (Basel, Switzerland) (2024)
Progressive Multifocal Leukoencephalopathy (PML) is a possibly fatal demyelinating disease and John Cunningham Polyomavirus (JCPyV) is believed to cause this condition. The so-called JCPyV was initially reported in lymphoma and Human Immunodeficiency Virus (HIV) cases, whereas nowadays, its incidence is increasing in Multiple Sclerosis (MS) cases treated with natalizumab (Tysabri). However, there are conflicting literature data on its pathology and diagnosis, whereas some misdiagnosed reports exist, giving rise to further questions towards the topic. In reality, the so-called PML and the supposed JCPyV are not what they seem to be. In addition, novel and more frequent PML-like conditions may be reported, especially after the Coronavirus Disease 2019 (COVID-19) pandemic.
Keyphrases
- multiple sclerosis
- human immunodeficiency virus
- antiretroviral therapy
- hepatitis c virus
- coronavirus disease
- hiv infected
- hiv positive
- white matter
- hiv aids
- systematic review
- electronic health record
- hiv testing
- risk factors
- emergency department
- men who have sex with men
- big data
- respiratory syndrome coronavirus
- artificial intelligence
- sars cov
- data analysis