Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis.
Petri EloSina TadayonHeidi LiljenbäckJarmo TeuhoMeeri KäkeläKalle KoskensaloVirva SaunavaaraJenni VirtaTibor Z VeresAida KiviniemiAntti SarastePäivi MarjamäkiLaura AirasSirpa JalkanenAnne RoivainenPublished in: Journal of neuroinflammation (2018)
Our results revealed that VAP-1 is expressed and functionally active in vasculature within the induced focal EAE lesions during the acute phase of inflammation and remains expressed after the acute inflammation has subsided. The study indicates that VAP-1 is actively involved in the development of inflammatory CNS lesions. During this process, the endothelial cell lesion-related vasculature seem to undergo a structural transformation from regular flat-walled endothelium to HEV-like endothelium.
Keyphrases
- oxidative stress
- multiple sclerosis
- diabetic rats
- nitric oxide
- drug induced
- high glucose
- endothelial cells
- liver failure
- blood brain barrier
- intensive care unit
- respiratory failure
- pseudomonas aeruginosa
- protein protein
- staphylococcus aureus
- hepatitis b virus
- cell migration
- acute respiratory distress syndrome
- cell adhesion