One-Pot Synthesis of ( E )-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles.
Nicolai A AksenovAlexander V AksenovIgor A KurenkovNikita K KirillovDmitrii A AksenovNikolai A ArutiunovDaria S AksenovaMichael RubinPublished in: Molecules (Basel, Switzerland) (2022)
A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho -nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction.
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