Recently we showed the reduction and oxidation of six natural 2'-deoxynucleosides in the presence of the ambient oxygen using the very broad potential window of a pyrolytic graphite electrode (PGE). Using the same procedure, 2'-deoxynucleoside analogs (dNs) that are parts of an artificially expanded genetic information system (AEGIS) were analyzed. Seven of the eight tested AEGIS dNs provided specific signals (voltammetric redox peaks). These signals, described here for the first time, will be used in future work to analyze DNA built from expanded genetic alphabets, helping to further develop AEGIS technology and its applications. Comparison of the electrochemical behavior of unnatural dNs with the previously documented behaviors of natural dNs also provides insights into the mechanisms of their respective redox processes.
Keyphrases
- electron transfer
- molecularly imprinted
- gold nanoparticles
- genome wide
- hydrogen peroxide
- ionic liquid
- air pollution
- carbon nanotubes
- copy number
- particulate matter
- circulating tumor
- single molecule
- cell free
- molecular docking
- reduced graphene oxide
- minimally invasive
- nitric oxide
- high resolution
- health information
- climate change
- risk assessment
- nucleic acid
- molecular dynamics simulations