Production of a versatile SARS-CoV-2 main protease biosensor based on a dimerization-dependent red fluorescent protein.

we designed a functionally active Mpro biosensor based on a dimerization-dependent red fluorescent protein (ddRFP) for the evaluation of Mpro inhibitors in vitro. This study provides an affordable strategy for rapid production of a versatile ddRFP biosensor, which would be a useful tool for the measurement and quantification of Mpro inhibitors This article is protected by copyright. All rights reserved.