The Potential Benefic Effect of Nicotinamide Riboside in Treating a Murine Model of Monoiodoacetate-Induced Knee Osteoarthritis.
Florin-Liviu GherghinaIon MîndrilăSandra-Alice ButeicăGeorge BicăCătălina-Gabriela PisoschiCristina-Elena BițăIulia-Alexandra PaliuOtilia-Constantina RogoveanuPublished in: Journal of clinical medicine (2023)
Knee osteoarthritis (KOA), one of the most common orthopedic disorders concerning the adult population worldwide, is a condition characterized by progressive destruction of the articular cartilage and the presence of an inflammatory process. The aim of our study was to assess whether nicotinamide riboside (NR), a popular anti-aging supplement, can reduce the rate of cartilage destruction and alleviate the inflammatory response compared to the commonly prescribed collagen supplement in a murine monoiodoacetate (MIA)-induced KOA model. Twenty Wistar rats were randomly assigned to 4 groups: sham (S), MIA and NR, MIA and hydrolyzed collagen (HC), and MIA. At the end of the experiment, the right knees and blood samples were collected for histological assessment and biochemical evaluation of nitric oxide, malondialdehyde, total antioxidant capacity, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase, myeloperoxidase, and tumoral necrosis factor-alpha (TNF-α). The study determined that the treatment with NR in a similar dose with HC decreased blood/serum levels of oxidative stress biomarkers and the histological lesions in almost the same manner. The present findings suggest that NR may exhibit chondroprotective and anti-inflammatory effects in MIA-induced KOA in rats.
Keyphrases
- knee osteoarthritis
- diabetic rats
- oxidative stress
- nitric oxide
- inflammatory response
- high glucose
- hydrogen peroxide
- drug induced
- rheumatoid arthritis
- multiple sclerosis
- endothelial cells
- ischemia reperfusion injury
- signaling pathway
- lipopolysaccharide induced
- lps induced
- toll like receptor
- heat shock
- smoking cessation
- clinical evaluation