Dysregulation of the Retromer Complex System in Down Syndrome.
Mary Elizabeth CurtisDaohai YuDomenico PraticoPublished in: Annals of neurology (2020)
We conclude that dysregulation of the retromer complex system is an early event in the development of the AD-like pathology and cognitive decline in DS, and for this reason the system could represent a novel potential therapeutic target for DS. ANN NEUROL 2020 ANN NEUROL 2020;88:137-147.