Dietary Potassium Supplementation Reduces Chronic Kidney Lesions Independent of Blood Pressure in Deoxycorticosterone-Acetate and High Sodium Chloride-Treated Mice.
Qing WangStephan C SchäferJacques-Antoine HaefligerMarc P MaillardFlorian AlonsoPublished in: International journal of molecular sciences (2023)
We have previously shown that an excess of deoxycorticosterone acetate and high sodium chloride intake (DOCA/salt) in one-renin gene mice induces a high urinary Na/K ratio, hypokalemia, and cardiac and renal hypertrophy in the absence of hypertension. Dietary potassium supplementation prevents DOCA/salt-induced pathological processes. In the present study, we further study whether DOCA/salt-treated mice progressively develop chronic inflammation and fibrosis in the kidney and whether dietary potassium supplementation can reduce the DOCA/salt-induced renal pathological process. Results showed that (1) long-term DOCA/salt-treated one-renin gene mice developed severe kidney injuries including tubular/vascular hypertrophy, mesangial/interstitial/perivascular fibrosis, inflammation (lymphocyte's immigration), proteinuria, and high serum creatinine in the absence of hypertension; (2) there were over-expressed mRNAs of plasminogen activator inhibitor-1 (PAI-1), fibronectin, collagen type I and III, interferon-inducible protein-10 (IP-10), monocyte chemotactic protein-1 (MCP1), transforming growth factor- β (TGF- β ), tumor necrosis factor-alpha (TNF- α ), osteopontin, Nuclear factor kappa B (NF-κB)/P65, and intercellular adhesion molecule (ICAM)-1; and (3) dietary potassium supplementation normalized urinary Na/K ratio, hypokalemia, proteinuria, and serum creatinine, reduced renal hypertrophy, inflammations, and fibrosis, and down-regulated mRNA expression of fibronectin, Col-I and III, TGF- β , TNF- α , osteopontin, and ICAM without changes in the blood pressure. The results provide new evidence that potassium and sodium may modulate proinflammatory and fibrotic genes, leading to chronic renal lesions independent of blood pressure.
Keyphrases
- blood pressure
- nuclear factor
- transforming growth factor
- high glucose
- high fat diet induced
- hypertensive patients
- rheumatoid arthritis
- oxidative stress
- drug induced
- toll like receptor
- epithelial mesenchymal transition
- heart rate
- genome wide
- endothelial cells
- dendritic cells
- genome wide identification
- escherichia coli
- systemic sclerosis
- small molecule
- insulin resistance
- protein protein
- copy number
- early onset
- heart failure
- genome wide analysis
- peripheral blood
- transcription factor
- adipose tissue
- metabolic syndrome
- uric acid
- stress induced
- type iii
- newly diagnosed
- left ventricular
- candida albicans