Antineutrophil cytoplasmic antibody profiles differ according to type of primary sclerosing cholangitis and autoimmune hepatitis.

Juliana Goldbaum Crescente Alessandra Dellavance Marcio Augusto Diniz Flair Jose Carrilho Luis Eduardo Coelho de Andrade Eduardo Luiz Rachid Cançado

Published in: Clinics (Sao Paulo, Brazil) (2021)

PSC/IBD+ differed from PSC/IBD- in terms of sex and proteinase 3-ANCA and atypical perinuclear-ANCA reactivity, the latter of which was more frequently detected in type-1 and type-3 AIH than in type-2 AIH. There was no agreement between ANCA patterns and antigenic specificities in IBD and autoimmune liver diseases, which reinforces the need for proteinase-3 and myeloperoxidase antibody testing.

Keyphrases

multiple sclerosis
ulcerative colitis