Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.
Renata FerrarottoYoshitsugu MitaniDaniel J McGrailKaiyi LiTatiana V KarpinetsDiana BellSteven J FrankXingzhi SongMichael E KupfermanBin LiuJiun-Kae Jack LeeBonnie S GlissonJianhua ZhangJon C AsterShiaw-Yih LinP Andrew FutrealJohn Victor HeymachAdel K El-NaggarPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Cooccurrence of multiple actionable protein/pathways alterations in each subtype indicates unique therapeutic vulnerabilities and opportunities for optimal combination therapy for this understudied and heterogeneous disease.