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Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Renata FerrarottoYoshitsugu MitaniDaniel J McGrailKaiyi LiTatiana V KarpinetsDiana BellSteven J FrankXingzhi SongMichael E KupfermanBin LiuJiun-Kae Jack LeeBonnie S GlissonJianhua ZhangJon C AsterShiaw-Yih LinP Andrew FutrealJohn Victor HeymachAdel K El-Naggar
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Cooccurrence of multiple actionable protein/pathways alterations in each subtype indicates unique therapeutic vulnerabilities and opportunities for optimal combination therapy for this understudied and heterogeneous disease.
Keyphrases
  • genome wide
  • high grade
  • protein protein
  • amino acid
  • binding protein
  • dna methylation