CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway.

Lei WangYehui ZhouLiang JiangLinlin LuTiantian DaiAoshuang LiYan ChenLifeng Zhang

Published in: Molecular cancer (2021)

CircWAC/miR-142/WWP1 form a competing endogenous RNA (ceRNA) network to regulate PI3K/AKT signaling activity in TNBC cells and affect the chemosensitivity of cells.

Keyphrases

cell cycle arrest
pi k akt
cell proliferation
signaling pathway
induced apoptosis
long non coding rna
cell death