Histone deacetylase inhibitor decreases hyperalgesia in a mouse model of alcohol withdrawal-induced hyperalgesia.

Jhoan AguilarLuana Martins De CarvalhoHu ChenRyan Condon Amy W Lasek Amynah Amir Ali Pradhan

Published in: Alcohol, clinical & experimental research (2024)

These results demonstrate AWH in mice after chronic binge drinking in males and after Lieber-DeCarli liquid diet administration in both sexes. Like previous findings in rats, HDAC inhibition reduced AWH in mice, suggesting that epigenetic mechanisms are involved in AWH.

Keyphrases

histone deacetylase
mouse model
high fat diet induced
neuropathic pain
dna methylation
alcohol consumption
high glucose
physical activity
ionic liquid
type diabetes
insulin resistance
spinal cord
wild type
endothelial cells
adipose tissue