CA9 knockdown enhanced ionizing radiation-induced ferroptosis and radiosensitivity of hypoxic glioma cells.

Wenpeng HuangYuping HeShuangyu YangXuefei XueHualong QinTing SunWei Yang

Published in: International journal of radiation biology (2023)

Ionizing radiation can induce ferroptosis in glioma cells. CA9 knockdown can enhance the radiosensitivity of hypoxic glioma cells and overcome the resistance of ferroptosis under hypoxia. Enhancing ferroptosis will become a new idea to improve the efficacy of radiotherapy for glioma.

Keyphrases

cell death
early stage
high glucose
endothelial cells
radiation therapy
protein kinase
squamous cell carcinoma
drug induced