The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor.

Li LiuJing ZhengXian-Feng HuangXia ZhuShu-Ming DingHeng-Ming KeJames M O'DonnellHan-Ting ZhangGuo-Qiang SongYing Xu

Published in: CNS neuroscience & therapeutics (2018)

These results suggest that the novel PDE2 inhibitor Hcyb1 produced neuroprotective and antidepressant-like effects most likely mediated by cAMP/cGMP-CREB-BDNF signaling.

Keyphrases

major depressive disorder
cerebral ischemia
nitric oxide
protein kinase
bipolar disorder
binding protein
stress induced