MEK1/2 and ERK1/2 mediated lung endothelial injury and altered hemostasis promote diffuse alveolar hemorrhage in murine lupus.

Haoyang Zhuang Shuhong HanNeil S HarrisWestley H Reeves

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

Pristane treatment promotes lung endothelial injury and DAH in B6 mice by activating the MEK1/2-ERK1/2 pathway and impairing hemostasis. The hereditary factors determining susceptibility to lung injury and bleeding in pristane-induced lupus are relevant to the pathophysiology of life-threatening DAH in SLE and may help to optimize therapy.

Keyphrases

systemic lupus erythematosus
pi k akt
signaling pathway
disease activity
endothelial cells
cell proliferation
high glucose
rheumatoid arthritis
high fat diet induced
type diabetes
low grade
stem cells
insulin resistance
skeletal muscle
oxidative stress