ESMO Scale for Clinical Actionability of Molecular Targets Driving Targeted Treatment in Patients with Cholangiocarcinoma.

Helena VerdaguerTamara SauríDaniel Alejandro AcostaMagdalena GuardiolaAlexandre SierraJorge HernandoPaolo G NuciforoJosep M MiquelCristina MoleroSandra PeiróQueralt Serra-CamprubíGuillermo VillacampaSusana AguilarAna VivancosJosep TaberneroRodrigo DienstmannTeresa Macarulla

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

ESCAT represents a tool to guide clinicians in fine-tuning use of molecular profiling data to choose matched targeted therapies. Our data demonstrate that targeted treatment administered per alteration actionability according to ESCAT is associated with improved survival in cholangiocarcinoma, particularly in ESCAT I-II intrahepatic cholangiocarcinoma.

Keyphrases

electronic health record
big data
cancer therapy
single cell
drug delivery
artificial intelligence