TLR7 activation in epilepsy of tuberous sclerosis complex.

Alan A DombkowskiDaniela CukovicShruti BaglaMcKenzie JonesJoseph A CarusoHarry T ChuganiDiane C Chugani

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)

TLR7 activation by microRNAs may contribute to the neuroinflammatory cascade in epilepsy in TSC. Further characterization of this mechanism may enable the combined of use of neuroimaging and TLR7 inhibitors in a personalized approach towards the treatment of intractable epilepsy.

Keyphrases

toll like receptor
inflammatory response
immune response
temporal lobe epilepsy
nuclear factor
combination therapy
replacement therapy