Endoplasmic reticulum-unfolded protein response signalling is altered in severe eosinophilic and neutrophilic asthma.

Prabuddha S PathinayakeDavid W WatersKristy S NicholAlexandra C BrownAndrew T ReidAlan Chen-Yu HsuJay C HorvatLisa G WoodKatherine J BainesJodie Louise SimpsonPeter G GibsonPhilip M HansbroPeter A B Wark

Published in: Thorax (2021)

Heightened ER stress is associated with severe eosinophilic and neutrophilic inflammation in asthma and may play a crucial role in the pathogenesis of asthma.

Keyphrases

endoplasmic reticulum
chronic obstructive pulmonary disease
lung function
allergic rhinitis
early onset
oxidative stress
cystic fibrosis
air pollution
chronic rhinosinusitis
drug induced
amino acid