A metabolic pacer ensures smooth running of the lymphocyte activation race.

Published in: Science immunology (2024)

Upon lymphocyte stimulation, accumulation of intracellular NAD(H) reflects the strength of antigen receptor signals and controls the rate of cell cycle entry and proliferation (see related Research Article by Turner et al .).

Keyphrases

cell cycle
cell proliferation
peripheral blood
signaling pathway
high intensity
reactive oxygen species
binding protein