Thiopurines have longer treatment durability than methotrexate in adults and children with Crohn's Disease: a nationwide analysis from the epi-IIRN cohort.

Ohad AtiaChagit FrissNatan LeddermanShira GreenfeldRevital KarivSaleh DaherHenit YanaiYiska Loewenberg WeisbandEran MatzIris DotanDan Turner

Published in: Journal of Crohn's & colitis (2023)

Thiopurines demonstrated higher treatment durability than methotrexate but more frequent adverse events. However, disease outcomes were similar, partly due to more frequent escalation to biologics with methotrexate.

Keyphrases

high dose
young adults
type diabetes
metabolic syndrome
clinical trial
study protocol
insulin resistance
smoking cessation
combination therapy
replacement therapy