White adipose tissue-infiltrated CD11b+ myeloid cells are a source of S100A4, a new potential marker of hepatic damage.
Marjorie ReyesLorena GonzálezKevin IbeasRubén CereijoSiri D TaxeråsSilvia PelliteroEva MartínezJordi TarascóPau MorenoPaloma MalagónCarmen HiguerasAndrea SoriaManel Puig-DomingoFrancesc VillarroyaDolors SerraLaura HerreroDavid Sánchez-InfantesPublished in: European journal of endocrinology (2021)
Our data suggest that sWAT-infiltrated CD11b+ cells could be a major source of S100A4 in obesity. Moreover, our correlations identify circulating S100A4 as a potential novel biomarker of hepatic damage and steatosis.
Keyphrases
- insulin resistance
- adipose tissue
- oxidative stress
- induced apoptosis
- high fat diet
- high fat diet induced
- metabolic syndrome
- weight loss
- type diabetes
- human health
- cell cycle arrest
- electronic health record
- acute myeloid leukemia
- nk cells
- skeletal muscle
- big data
- dendritic cells
- physical activity
- risk assessment
- body mass index
- endoplasmic reticulum stress