Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury.

Yuhao XuLimoran TangChao ZhouLiang SunYujie HuZhi ZhangShengnan XiaXinyu BaoHaiyan YangYun Xu

Published in: CNS neuroscience & therapeutics (2024)

ADORA3 antagonist alleviates chronic ischemic WMI by modulating myelin clearance of microglia, which may be a potential therapeutic target for the treatment of VaD.

Keyphrases

white matter
inflammatory response
neuropathic pain
ischemia reperfusion injury
multiple sclerosis
mouse model
signaling pathway
cerebral ischemia