Stretchable and Photocatalytically Renewable Electrochemical Sensor Based on Sandwich Nanonetworks for Real-Time Monitoring of Cells.
Ya-Wen WangYan-Ling LiuJia-Quan XuYu QinWei-Hua HuangPublished in: Analytical chemistry (2018)
Stretchable electrochemical (EC) sensors have broad prospects in real-time monitoring of living cells and tissues owing to their excellent elasticity and deformability. However, the redox reaction products and cell secretions are easily adsorbed on the electrode, resulting in sensor fouling and passivation. Herein, we developed a stretchable and photocatalytically renewable EC sensor based on Au nanotubes (NTs) and TiO2 nanowires (NWs) sandwich nanonetworks. The external Au NTs are used for EC sensing, and internal TiO2 NWs provide photocatalytic performance to degrade contaminants, which endows the sensor with excellent EC performance, high photocatalytic activity, and favorable mechanical tensile property. This allows highly sensitive recycling monitoring of NO released from endothelial cells and 5-HT released from mast cells under their stretching states in real time, therefore providing a promising tool to unravel elastic and mechanically sensitive cells, tissues, and organs.
Keyphrases
- visible light
- living cells
- reduced graphene oxide
- induced apoptosis
- gold nanoparticles
- fluorescent probe
- endothelial cells
- cell cycle arrest
- gene expression
- sensitive detection
- molecularly imprinted
- single cell
- signaling pathway
- quantum dots
- stem cells
- oxidative stress
- single molecule
- cell death
- drinking water
- current status
- cell therapy
- high resolution
- highly efficient
- pi k akt
- mesenchymal stem cells
- electron transfer