Anthropometric Measurements and Admission Parameters as Predictors of Acute Respiratory Distress Syndrome in Hospitalized COVID-19 Patients.
Vladimir ZdravkovićĐorđe StevanovićNeda ĆićarićNemanja ZdravkovićIvan ČekerevacMina PoskuricaIvan SimićVladislava StojićTomislav NikolićMarina MarkovićMarija PopovićAna DivjakDušan TodorovićMarina PetrovićPublished in: Biomedicines (2023)
Aim : We aimed to single out admission predictors of acute respiratory distress syndrome (ARDS) in hospitalized COVID-19 patients and investigate the role of bioelectrical impedance (BIA) measurements in ARDS development. Method : An observational, prospective cohort study was conducted on 407 consecutive COVID-19 patients hospitalized at the University Clinical Center Kragujevac between September 2021 and March 2022. Patients were followed during the hospitalization, and ARDS was observed as a primary endpoint. Body composition was assessed using the BMI, body fat percentage (BF%), and visceral fat (VF) via BIA. Within 24 h of admission, patients were sampled for blood gas and laboratory analysis. Results : Patients with BMI above 30 kg/m 2 , very high BF%, and/or very high VF levels were at a significantly higher risk of developing ARDS compared to nonobese patients (OR: 4.568, 8.892, and 2.448, respectively). In addition, after performing multiple regression analysis, six admission predictors of ARDS were singled out: (1) very high BF (aOR 8.059), (2) SaO 2 < 87.5 (aOR 5.120), (3) IL-6 > 59.75 (aOR 4.089), (4) low lymphocyte count (aOR 2.880), (5) female sex (aOR 2.290), and (6) age < 68.5 (aOR 1.976). Conclusion : Obesity is an important risk factor for the clinical deterioration of hospitalized COVID-19 patients. BF%, assessed through BIA measuring, was the strongest independent predictor of ARDS in hospitalized COVID-19 patients.
Keyphrases
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- body composition
- mechanical ventilation
- end stage renal disease
- sars cov
- emergency department
- chronic kidney disease
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- magnetic resonance imaging
- intensive care unit
- type diabetes
- body mass index
- bone mineral density
- metabolic syndrome
- skeletal muscle
- postmenopausal women
- resistance training
- room temperature