Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability.

Alex de MendozaTrung Viet NguyenEthan FordDaniel PoppeSam BuckberryJahnvi PfluegerMatthew R GrimmerSabine StolzenburgOzren BogdanovicAlicia OshlackPeggy J FarnhamPilar BlancafortRyan Lister

Published in: Genome biology (2022)

These findings have important implications for epigenome engineering and demonstrate that the response of promoters to DNA methylation is more complex than previously appreciated.

Keyphrases

dna methylation
gene expression
genome wide
transcription factor
copy number
heat shock
oxidative stress