Hyperinflammatory Syndrome, Natural Killer Cell Function, and Genetic Polymorphisms in the Pathogenesis of Severe Dengue.

Nguyen Lam VuongKa Wai CheungBalamurugan PeriaswamyTran Thuy ViHuynh Thi Le DuyenYan Shan LeongZayanah Noor Binte HamisMichaela GregorovaEng-Eong OoiOctober SessionsLaura RivinoSophie Yacoub

Published in: The Journal of infectious diseases (2022)

Features of hyperinflammation are associated with dengue severity, including higher biomarkers, impaired NK cell function, and polymorphisms in NK cell cytolytic function genes (KLRK1 and PRF1). Trials of immunomodulatory therapy in these patients is now warranted.

Keyphrases

nk cells
zika virus
end stage renal disease
dengue virus
ejection fraction
aedes aegypti
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
stem cells
genome wide
dna methylation
transcription factor
bone marrow