Agreement Between Published Reference Resources for Neurofilament Light Chain Levels in People With Multiple Sclerosis.

Interpretation of blood NfL values may vary markedly depending on the selection of the reference resource. Borderline elevated values should be interpreted with caution and future studies should focus on standardizing NfL measurement and reporting across laboratories/platforms, better characterizing the effects of confounding/influencing factors, and defining the performance of NfL (including as part of multi-modal predictive algorithms) for prediction of disease-specific outcomes.