Neuropharmacokinetic evaluation of lactoferrin-treated indinavir-loaded nanoemulsions: remarkable brain delivery enhancement.

Zahra Karami Mohammad Reza Saghatchi Zanjani Saeed Rezaee Kobra Rostamizadeh Mehrdad Hamidi

Published in: Drug development and industrial pharmacy (2019)

It can be concluded that applying both lactoferrin-treated and non-treated nanoemulsions clearly leads to significant brain penetration enhancement of indinavir, an effect which is more pronounced in the case of Lf-IDV-NEs with the higher drug residence time in brain.

Keyphrases

resting state
white matter
functional connectivity
emergency department
cancer therapy
blood brain barrier
brain injury
subarachnoid hemorrhage