Pre- and postnatal Lactobacillus reuteri treatment alters DNA methylation of infant T helper cells.

Anna ForsbergJohanna Huoman Simon SöderholmRatnesh Bhai MehtaLennart Jan NilssonThomas R AbrahamssonJan ErnerudhMika GustafssonMaria C Jenmalm

Published in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2020)

Maternal L. reuteri supplementation during pregnancy alters DNA methylation patterns in CD4+ T cells towards enhanced immune activation at birth, which may affect immune maturation and allergy development.

Keyphrases

dna methylation
genome wide
induced apoptosis
gene expression
cell cycle arrest
preterm infants
pregnancy outcomes
dendritic cells
regulatory t cells
birth weight
gestational age
oxidative stress
pregnant women
copy number
combination therapy
immune response
preterm birth
infectious diseases
weight gain