Prediction of Kidney Drug Clearance: A Comparison of Tubular Secretory Clearance and Glomerular Filtration Rate.

Yan ChenLeila R Zelnick Andrew N HoofnagleCatherine K YeungLaura M ShiremanBrian PhillipsCalder C BrauchlaIan H de BoerLinda ManahanSusan R HeckbertJonathan HimmelfarbBryan R Kestenbaum

Published in: Journal of the American Society of Nephrology : JASN (2020)

Secretory solute clearance measurements can predict kidney drug clearances. However, tight linkage between GFR and proximal tubular secretory clearance in stable outpatients provides some reassurance that GFR, even when estimated, is a useful surrogate for predicting secretory drug clearances in such patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
blood brain barrier
drug induced
emergency department
high glucose
patient reported outcomes
endothelial cells