Autophagy in non-immune-mediated rhabdomyolysis: Assessment of p62 immunohistochemistry.

Ignacio Javier AcostaWerner StenzelMonika HoferStefen Brady

Published in: Muscle & nerve (2022)

Disturbance of autophagy appears to be a common mechanism in non-immune-mediated rhabdomyolysis. Our results show p62 IHC is sensitive but lacks specificity. Therefore, the pattern of p62 staining does not distinguish non-immune-mediated rhabdomyolysis from histopathologically similar IMNM.

Keyphrases

acute kidney injury
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress