The Impact of Inherited Genetic Variation on DNA Methylation in Prostate Cancer and Benign Tissues of African American and European American Men.
Dayana DelgadoMarc GillardLin TongKathryn DemanelisMeritxell OlivaKevin J GleasonMeytal Batya ChernoffLin S ChenGladell P PanerDonald J Vander GriendBrandon L PiercePublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2024)
Overall, our findings showed general consistency in the meQTL landscape of AA and EA men, but meQTLs often differ by tissue type (normal vs. cancer). Ancestry-based linkage disequilibrium differences and lack of AA representation in GWAS decrease statistical power to detect colocalization for some regions.
Keyphrases
- african american
- prostate cancer
- dna methylation
- genome wide
- gene expression
- papillary thyroid
- radical prostatectomy
- squamous cell
- genome wide association study
- lymph node metastasis
- single cell
- hiv testing
- copy number
- hepatitis c virus
- young adults
- antiretroviral therapy
- hiv infected
- men who have sex with men
- neural network