Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats.
Chin-Yi ChengSu-Yin ChiangShung-Te KaoShang-Chih HuangPublished in: Chinese medicine (2021)
YZR-0.4 g and YZR-0.8 g treatments exerted beneficial effects on cerebral ischemic injury by downregulating JNK-mediated signaling in the peri-infarct cortex. Moreover, the anti-infarction effects of YZR extract treatments were partially attributed to the downregulation of JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling pathways in the penumbral cortex at 1 day after reperfusion.
Keyphrases
- cerebral ischemia
- signaling pathway
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- oxidative stress
- induced apoptosis
- cell death
- toll like receptor
- immune response
- inflammatory response
- pi k akt
- acute myocardial infarction
- functional connectivity
- cell proliferation
- epithelial mesenchymal transition
- coronary artery disease
- acute coronary syndrome
- acute ischemic stroke
- drug induced
- ischemia reperfusion injury
- nuclear factor
- cerebral blood flow