Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344A > G mutation in the mitochondrial tRNA Lys .

Mariantonietta CapristoValentina Del DottoConcetta Valentina TropeanoClaudio FioriniLeonardo CaporaliChiara La MorgiaMaria Lucia ValentinoMonica MontopoliValerio CarelliAlessandra Maresca

Published in: Molecular medicine (Cambridge, Mass.) (2022)

Overall, our results point to rapamycin-based therapy as a promising therapeutic option for MERRF.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
mouse model
endoplasmic reticulum stress
signaling pathway
stem cells
cell death
mesenchymal stem cells