Systematic Review and Meta-analysis of the Most Common Genetic Mutations in Esophageal Squamous Cell Carcinoma.

Amirreza Naseri Hanieh Salehi Pourmehr Reza Majidazar Parya Seraji Erfan Rezazadeh GavganiMojtaba ZehtabiHamed Kiani-KezbinFatemeh SalehniaSina Hassannezhad Arash Hajikamanj Mortaza Raeisi

Published in: Journal of gastrointestinal cancer (2021)

This systematic review and meta-analysis revealed that more than 10% of ESCC patients had changes in TP53, CCND1, MDM2, NOTCH1/2/3, KMT2D, CDKN2A, PIK3CA, and FAT1 genes, which can highlight their role in developing ESCC. TP53, CCND1, and MDM2 are the most prevalent, demonstrating 68.6%, 39.3%, and 24.9% of the mutations in ESCC patients.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
adipose tissue
cell proliferation
gene expression
dna methylation
single cell