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In-silico and in-vitro evidence suggest LINC01405 as a sponge for miR-29b and miR-497-5p, and a potential regulator of Wnt, PI3K, and TGFB signaling pathways in breast carcinoma.

Romina NorouziZahra MohamadzadeRambod NorouziRadin NorouziRezvan EsmaeiliBahram Mohammad Soltani
Published in: Cancer reports (Hoboken, N.J.) (2024)
We revealed the differential expression of LINC01405 in several types of breast cancer and its role in regulating signaling pathways, potentially via scavenging miRNAs. These findings clarified the role of LINC01405 in breast cancer development and identified potential therapeutic targets.
Keyphrases
  • long non coding rna
  • cell proliferation
  • long noncoding rna
  • signaling pathway
  • pi k akt
  • stem cells
  • human health
  • single cell
  • risk assessment
  • young adults
  • climate change