Detection of a Multiple Circulation Event of Dengue Virus 2 Strains in the Northern Region of Brazil.
Murilo Tavares AmorimFelipe Gomes NavecaLeonardo Henrique Almeida HernándezThito Yan Bezerra da PazCintia Cryslaine da Silva de OliveiraAlessandra da Conceição Miranda SantosAlice Louize Nunes QueirozAna Lucia Monteiro WanzellerEliana Vieira Pinto da SilvaFábio Silva da SilvaSandro Patroca da SilvaBruno Tardelli Diniz NunesAna Cecília Ribeiro CruzPublished in: Tropical medicine and infectious disease (2024)
Dengue virus serotype 2 (DENV-2) is responsible for dengue epidemics on a global scale and is associated with severe cases of the disease. This study conducted a phylogenetic investigation of DENV-2 isolates from 2017 to 2021 originating from the northern states of Brazil. A total of 32 samples from DENV-2 isolates were analyzed, including 12 from Acre, 19 from Roraima, and one from Tocantins. Only one lineage of the Asian-American genotype and one lineage of the cosmopolitan genotype were observed: Lineage 1, Asian-American genotype (connection to Puerto Rico); Lineage 5, cosmopolitan genotype (connection to Peru). Our results provide important data regarding the study of DENV genotypes and lineage distribution and open up possibilities for probable introduction and dissemination routes.