Aromatase (CYP19A1) gene variants, sex steroid levels, and late-life depression.

Marie-Laure AncelinJoanna NortonMarianne CanonicoPierre-Yves ScarabinKaren RitchieJoanne Ryan

Published in: Depression and anxiety (2019)

Variants of the CYP19A1 gene appear to be susceptibility factors for late-life depression in a sex-specific manner. The polymorphisms decreasing the risk of recurrent depression in postmenopausal women also influence estradiol levels.

Keyphrases

postmenopausal women
copy number
depressive symptoms
bone mineral density
sleep quality
genome wide
dna methylation
physical activity
estrogen receptor
transcription factor