Association of prothrombin complex concentrate administration and hematoma enlargement in non-vitamin K antagonist oral anticoagulant-related intracerebral hemorrhage.
Stefan T GernerJoji B KuramatsuJochen A SembillMaximilian I SprügelMatthias EndresKarl Georg HaeuslerPeter VajkoczyPeter A RinglebJan Christoph PurruckerTimolaos RizosFrank ErbguthPeter D SchellingerGereon R FinkHenning StetefeldHauke SchneiderHermann NeugebauerJoachim RötherJoseph ClaßenDominik MichalskiArnd DörflerStefan SchwabHagen B Huttnernull nullPublished in: Annals of neurology (2019)
In contrast to blood pressure control, PCC administration was not associated with a reduced rate of hematoma enlargement in NOAC-related ICH. Our findings support the need of further investigations exploring new hemostatic reversal strategies for patients with factor Xa inhibitor-related ICH. Ann Neurol 2018;83:186-196.