Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study.

Laura K KjærVanja CejvanovicTrine HenriksenKasper M PetersenTorben HansenOluf PedersenCramer K ChristensenChristian Torp-PedersenThomas A GerdsIvan BrandslundThomas Mandrup-PoulsenHenrik E Poulsen

Published in: Diabetes care (2017)

We conclude that high RNA oxidation is associated with all-cause and cardiovascular mortality risk in patients with type 2 diabetes. Targeting oxidative stress via interventions with long-term follow-up may reveal the predictive potential of the biomarker 8-oxoGuo.

Keyphrases

oxidative stress
hydrogen peroxide
physical activity
nucleic acid
dna damage
genome wide
single cell
cancer therapy
ischemia reperfusion injury
electron transfer
nitric oxide
risk assessment
visible light
drug delivery