Off-label drug use in neonates and infants in Spain: A five-year observational study.
Irene Lizano-DíezJoseph KargodorianMaría Ángeles Piñero-LópezCecilia F LastraEduardo L MariñoPilar ModamioPublished in: Pharmacoepidemiology and drug safety (2021)
Off-label use of drugs remains as an important public health concern, especially for neonates and infants up to 1 year, who receive the greatest proportion of off-label prescriptions. The evidence-based off-label prescription is a widespread practice that has shown a stable trend during the 5-year study period providing also a certain extent of flexibility to paediatricians in some therapeutic decisions.