Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells.

Arsen OsipovAlex B BlairJuliane LibertoJianxin WangKeyu LiBrian HerbstYao XuShiqi LiNan NiuRufiaat RashidDing DingYanan LiuZaiqi WangChristopher L WolfgangRichard A BurkhartDaniel LaheruLei Zheng

Published in: Cancer biology & medicine (2021)

These results support the clinical development of FAKi as a radiosensitizer for PDAC and combining FAKi with RT to prime the tumor microenvironment of PDAC for immunotherapy.

Keyphrases

radiation therapy
biofilm formation
protein kinase
tyrosine kinase
radiation induced
pseudomonas aeruginosa
staphylococcus aureus
cell adhesion
rectal cancer