Outcomes of kidney transplant recipients admitted to the intensive care unit: a retrospective study of 200 patients.
Damien GuinaultArnaud Del BelloLaurence LavayssiereMarie-Béatrice NogierOlivier CointaultNicolas CongyLaure EspositoAnne-Laure HebralOlivier RoquesNassim KamarStanislas FaguerPublished in: BMC anesthesiology (2019)
Notwithstanding the potential biases related to the retrospective and monocentric nature of this study, our findings obtained in a large cohort of KTR suggest that survival of KTR admitted in ICU is good but in-ICU management of these patients may alter both survival and AKI to CKD transition, as well as HLA immunization. Further interventional studies, including systematic characterization of the Epstein Barr virus proliferation at the admission (i.e., a potential surrogate marker of an underlying immune paralysis and frailty) will need to address the optimal management of immunosuppressive regimen in ICU to improve survival but also renal and immunological outcomes.
Keyphrases
- end stage renal disease
- epstein barr virus
- chronic kidney disease
- ejection fraction
- intensive care unit
- newly diagnosed
- emergency department
- peritoneal dialysis
- prognostic factors
- type diabetes
- metabolic syndrome
- signaling pathway
- adipose tissue
- diffuse large b cell lymphoma
- insulin resistance
- human health
- weight loss