AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides.
Amanda Acevedo-JakeAndrew T BallMarzia GalliMikiembo KukwikilaMathieu DenisDaniel G SingletonAli TavassoliStephen Michael GoldupPublished in: Journal of the American Chemical Society (2020)
We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.