Prevalence of Multidrug-Resistant and ESBL-Producing Bacterial Pathogens in Patients with Chronic Wound Infections and Spinal Cord Injury Admitted to a Tertiary Care Rehabilitation Hospital.
Reem BinsuwaidanMohammad Aatif KhanRaghad H AlzahraniAljoharah M AldusaymaniNoura M AlmallouhiAlhanouf S AlsabtiSajjad AliOmar Sufyan KhanAmira M YoussefLina I AlnajjarPublished in: Antibiotics (Basel, Switzerland) (2023)
A pressure ulcer is defined as a skin lesion of ischemic origin, a condition that contributes to morbidity and mortality in patients with spinal cord injuries. The most common complication of ulcers is a bacterial infection. Antimicrobial therapy should be selected with caution for spinal cord injury patients since they have a high risk of developing multidrug-resistant (MDR) infections. The aim of this study was to determine the prevalence of different bacterial pathogens in patients with pressure ulcers admitted with spinal cord injuries. This was a retrospective single-center study that included adult patients aged 18 years and above, admitted with chronic pressure wounds after a spinal cord injury requiring hospitalization between 2015 and 2021. A total of 203 spinal cord injury patients with pressure ulcers were included in the study. Ulcers were commonly infected by Staphylococcus aureus , Pseudomonas aeruginosa , and Escherichia coli , and they were mostly located in the sacral and gluteal areas. More than half of the bacteria isolated from patients were sensitive to commonly tested antibiotics, while 10% were either MDR- or pan-drug-resistant organisms. Of the MDR bacterial isolates, 25.61% were methicillin-resistant S. aureus , and 17.73% were extended-spectrum beta-lactamase Enterobacteriaceae. The most prevalent bacteria in pressure ulcers of spinal cord injury patients were S. aureus . Other antibiotic-resistant organisms were also isolated from the wounds.
Keyphrases
- multidrug resistant
- spinal cord injury
- drug resistant
- gram negative
- spinal cord
- staphylococcus aureus
- escherichia coli
- end stage renal disease
- acinetobacter baumannii
- pseudomonas aeruginosa
- klebsiella pneumoniae
- ejection fraction
- newly diagnosed
- neuropathic pain
- chronic kidney disease
- wound healing
- peritoneal dialysis
- healthcare
- emergency department
- tertiary care
- biofilm formation
- risk factors
- ischemia reperfusion injury
- drug induced
- patient reported