Obesity-induced nucleosome release predicts poor cardio-metabolic health.
Oriana Lo ReAndrea MaugeriJana HruskovaJuraj JakubikJan KuceraJulie Bienertova-VaskuJude A ObenLukas KubalaAdela DvorakovaMilan CizManlio VinciguerraPublished in: Clinical epigenetics (2019)
Neutrophils are a bona fide source of circulating nucleosomes in an obesogenic environment and in overweight/obese patients. High nucleosome levels are associated with MetS and cardiovascular performance, and might represent novel candidate biomarkers for cardio-metabolic health.
Keyphrases
- obese patients
- weight loss
- bariatric surgery
- healthcare
- public health
- mental health
- roux en y gastric bypass
- weight gain
- gastric bypass
- health information
- metabolic syndrome
- type diabetes
- insulin resistance
- physical activity
- high glucose
- diabetic rats
- oxidative stress
- body mass index
- high fat diet induced
- skeletal muscle
- climate change
- stress induced