Vaccines against the original strain of SARS-CoV-2 provide T cell memory to the B.1.1.529 variant.

Charlyn DörnteVerena TraskaNicole JansenJulia KostyraHerrad BaurmannGereon LauerYi-Ju HuangSven KramerOlaf BraunsHolger WinkelsJürgen SchmitzChristian DoseAnne RichterMarc Schuster

Published in: Communications medicine (2022)

The memory T cell response induced via first generation vaccination remains robust and is mostly unaffected by B.1.1.529 mutations. Correspondingly, in silico analyses of MHC presentation of epitopes derived from the B.1.1.529 Spike protein shows marginal differences compared to the ancestral SARS-CoV-2 strain.

Keyphrases

sars cov
working memory
respiratory syndrome coronavirus
high glucose
diabetic rats
molecular docking
protein protein
binding protein
drug induced
amino acid
oxidative stress
small molecule