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Fibroblast activation protein targeted therapy using [177Lu]FAPI-46 compared with [225Ac]FAPI-46 in a pancreatic cancer model.

Yuwei LiuTadashi WatabeKazuko Kaneda-NakashimaYoshifumi ShirakamiSadahiro NakaKazuhiro OoeAtsushi ToyoshimaKojiro NagataUwe HaberkornClemens KratochwilAtsushi ShinoharaJun HatazawaFrederik Giesel
Published in: European journal of nuclear medicine and molecular imaging (2021)
This study suggested the possible application of FAPI radioligand therapy in FAP-expressing pancreatic cancer. Further evaluation is necessary to find the best radionuclide with shorter half-life, as well as the combination with therapies targeting tumour cells directly.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • stem cells
  • cell death
  • mesenchymal stem cells