Reduction in MicroRNA-4488 Expression Induces NFκB Translocation in Venous Endothelial Cells Under Arterial Flow.
Shao-Yu FangChia-Wei HuangTzu-Chieh HuangAnjali YadavJeng-Jiann ChiuChia-Ching WuPublished in: Cardiovascular drugs and therapy (2020)
We showed that ALSS triggered the COX-2/NFκB pathway to induce vEC inflammation with a reduction in miR-4488. Combination of SC-236 and L-Arg prevented ALSS-induced vEC damage, thus, shows high potential for preventing vein graft diseases.
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